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Indirect biomarkers of exposure rely on measuring physiological indicators such as cytokine levels, chemokines, and oxidative stress markers, which may signal an immune or inflammatory response to MP presence [67] Although these methodologies offer promising directions, further research is required to validate their effectiveness, establish exposure thresholds, and standardize analytical procedures for consistent assessment across populations

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This method allows individuals to gradually wean themselves off nicotine while providing a steady supply that helps manage cravings